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Education B.Sc., Mechanical Engineering, Helwan Institute of Technology, 1980 M.Sc, ME, Mechanical Engineering, University of Michigan and Rice University, 1984, 1989 Ph.D., Mechanical Engineering, Rice University, 1990 Baylor College of Medicine, Respiratory System Mechanics, 1992 |
Aladin Boriek Baylor College of Medicine |
Department: Medicine Address: Suite 520B Baylor College of Medicine One Baylor Plaza Houston, Texas 77030 Phone: 713-798-6091 Fax: 713-798-3619 Email: boriek@bcm.tmc.edu Web: |
Boriek AM, et al. Desmin integrates the three-dimensional mechanical properties of muscles. Am J Physiol Cell Physiol. 280(1). C46-52, 2001. Appeared in the "ATS 2002 Year in Review". |
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Research Topic Respiratory muscle mechanics; computational models of tissue mechanics, mechanical role of structural proteins in skeletal and smooth muscles, mechanical signal transduction in skeletal and smooth muscles |
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I. Modeling diaphragm mechanics. Investigation of the determinants of diaphragm muscle mechanics and kinematics, including the unique mechanical properties of the diaphragm and structural issues such as the geodesic properties of diaphragm muscle fibers. Current works describe numerous approaches to dealing with these determinants, including measuring diaphragm curvature,displacement and muscle shortening, as well as computational modeling of the effect of muscle anisotropic properties on diaphragm shape. This work is established in collaboration with Drs. Rolf Hubmayr at Mayo Clinic and Dr. Theodore Wilson of the University of Minnesota. II. Modeling force transmission based on fiber architecture of skeletal muscles. Investigation of muscle fiber architecture of skeletal muscles including the diaphragm and abdominal muscles, and modeling the kinematics of single fiber mechanics during muscle shortening. Furthermore, we are interested in modeling the micro-mechanics of the fiber-connective tissue composite of the diaphragm muscle using computational methods for finite element modeling and analysis. In particular, we are interested in stress distribution in diaphragm muscle fibers and connective tissue as a result of muscle shortening. This work is established in collaboration with Drs. Joseph Rodarte of Baylor College of Medicine and James Tidball of UCLA. III. Modeling force transmission based on the structural arrangements of cytoskeletal proteins in skeletal muscles. Recently, we have been interested in development of models of force transmission in skeletal muscles at the molecular level using systems lacking specific structural proteins. Current work in this area includes developing detailed knowledge on the mechanical role of intercellular and extracellular members of the transmembrane protein network in skeletal muscles. These proteins include the intercellular proteins, desmin and dystrophin, the transmembrane protein, alpha7 integrin, and the extracellular protein, merosin (laminin-2). This work is established in collaboration with Drs. James Tidball of UCLA, Yassemi Capetanaki of Baylor College of Medicine and Ulrike Mayer of Max-Planck Institute in Germany. IV. Mechanical signal transduction. We are interested in signal transduction in skeletal and smooth muscles in response to mechanical forces. In particular we are interested in investigating the alteration in MAP kinase signaling pathways and the activation of the transcription factors like NfkappaB and AP-1 in response to mechanical stress. We are also interested in the regulation and modulation of pro-inflammatory genes in muscular dystrophy in response to mechanical forces. This work is conducted in collaboration with my colleague Dr. Ashok Kumar, a Research Instructor of Medicine, and a member of our research group. |
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