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Wah Chiu
Baylor College of MedicineDepartment: Biochemistry and Molecular BiologyAddress: One Baylor Plaza, N420 Alkek Building Houston, TX 77030 Phone: 713-798-6985 Fax: 713-798-8682 Email: wah@bcm.edu Web: ncmi.bcm.edu |
Education
B.A. Physics, University of California, Berkeley (1969)
Ph.D. Biophysics, University of California, Berkeley (1975)
Lawrence Berkeley National Laboratory (1979)
Honors
1986 Guggenheim Fellow
1996 Alexander von Humboldt Research Prize
1999 Research Fellow, Japan Society for the Promotion of Science
2003 Chinese Biophysicist Network Award
Research Topic
Structural and Computational Biology of Biological Machines
Research Description
Our research is focused on the development of the high throughput methodology for electron cryomicroscopy and computational methods to solve 3-dimensional structures of macromolecular machines towards atomic resolution. The biological applications of our methodology include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Research effort is made to derive functions of the machine components via computational approaches.
Selected Publications
- Zhou, Z. H., Dougherty, M., Jakana, J., He, J., Rixon, F. J. and Chiu, W. (2000) Seeing the herpesvirus capsid at 8.5 A, Science, 288: 877-880
- Zhou, Z. H., Baker, M. L., Jiang, W., Dougherty, M., Jakana, J., Dong, G., Lu, G. and Chiu, W. (2001) Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus. Nature Struct Biol, 8: 868-873.
- Schmid, M.F., Sherman, M., Matsudaira, P. and Chiu, W. (2004). Structure of the acrosomal bundle. Nature, 431, 104-107.
- Ludtke, S. J., Chen, D. H., Song, J. L., Chuang, D. T., and Chiu, W. (2004). Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. Structure 12, 1129-1136.
- Ludtke, S. J., Serysheva, II, Hamilton, S. L. and Chiu, W. (2005). The pore structure of the closed RyR1 channel. Structure (Camb) 13: 1203-11.
- Chiu, W., Baker, M.L., Jiang, W., Dougherty, M. and Schmid, M.F. (2005). Electron cryomicroscopy of biological machines at subnanometer resolution. Structure (Camb). 13:363-372.
- Jiang, W., Chang, J., Jakana, J. Weigele, P., King, J. and Chiu, W. (2006). Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature, 439: 612-6.
Lab Members
Current Graduate Students
Former Grad Students
Current Post Docs
Former Post Docs
Lab Photos
Last edited on: August 31, 2006