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B. V. Venkataram Prasad
Baylor College of MedicineDepartment: Biochemistry and Molecular BiologyAddress: Room N410, Alkek Building One Baylor Plaza Houston TX 77030 Phone: 713-798-5686 Fax: 713-798-1625 Email: vprasad@bcm.tmc.edu Web: |
Education
B.Sc (Hons)
M. Sc.
Ph.D. Biochemistry, University of Arizona
Department of Biochemistry, University of Arizona
Honors
Research Topic
Structural Basis of replication in RNA viruses
Research Description
Three-dimensional structural studies of gasteroenteric viruses; rotaviruses, calicivirus, and Norwalk virus.
Selected Publications
- Prasad, B.V. and Prevelige, P.E., Jr. (2003). Viral genome organization. Adv. Protein Chem. 64: 219-258.
- Pesavento, J.B., Billingsley, A.M., Roberts, E.J., Ramig, R.F. and Prasad, B.V. (2003). Structures of rotavirus reassortants demonstrate correlation of altered conformation of the VP4 spike and expression of unexpected VP4-associated phenotypes. J. Virol. 77: 3291-3296.
- Jayaram, H., Taraporewala, Z., Patton, J.T., and Prasad, B.V.V. (2002). Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold. Nature 417:311-5.
- Feng, N., Lawton, J.A., Gilbert, J., Kuklin, N., Prasad, B.V.V., and Greenberg, H.B. (2002). Mechanism of protection conferred by non-neutralizing, rotavirus VP6 specific IgA monoclonal antibody: a biological and structural analysis. J. Clinical Invest. 109: 1203-13.
- Pesavento, B., Lawton, J.A., Estes, M.K, and Prasad, B.V.V. (2001). The reversible condensation and expansion of the rotavirus genome. Proc. Natl. Academy. Sci. USA 98: 1381-1386.
- Crawford, S.E., Estes, M.K., Mukherjee, S.K., Lawton, J.A., Shaw, A.L., Ramig, R.F., Prasad, B.V.V. (2001). Trypsin cleavage stabilizes the rotavirus VP4 spike protein. J. Virol. 75:6052-6071.
- Mathieu, M., Petitpas, I., Kohli, E., Pothier, P., Prasad, B.V.V., Cohen, J., and Rey, F.A. (2001). Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion. EMBO J. 20: 1485-1497.
- Nason, E., Samal, S.K. and Prasad, B.V.V. (2000). Trypsin-induced structural transformation in aquareovirus. J. Virol. 74: 6546-6555.
- Lawton, J.A., Estes, M.K., and Prasad, B.V.V. (2000). Mechanism of genome transcription in segmented dsRNA viruses. Adv. Virus Res. 55: 185-229.
- Prasad, B.V.V., Hardy, M., Dokland, T., Bella, J., Rossmann, M.G. and Estes, M.K. (1999). Xray crystallographic structure of the Norwalk virus capsid. Science 286: 287-290.
- Lawton, J.A., Estes, M.K. and Prasad, B.V.V. (1999). Comparative structural analysis of transcriptionally-competent and incompetent rotavirus antibody complexes. Proc. Natl. Acad. Sci. USA 96: 5428-5433.
- Lawton, J.A., Estes, M.K. and Prasad, B.V.V. (1997). Three-dimensional visualization of mRNA release from actively transcribing rotavirus particles. Nat. Struct. Biol. 4: 118-121.
- Prasad, B.V.V., Rothnagel, R., Zeng, C.Q.-Y, Jakana, J., Lawton, J.A., Chou, W. and Estes, M.K. (1996). Visualization of the ordered genomic RNA and localization of the transcription complexes in rotavirus. Nature 382: 471-474.
Lab Members
Lab Photos
Last edited on: December 17, 2003