|
|
David Mittelman, Ph.D.
Baylor College of MedicineDepartment:Address: Phone: Fax: Email: david.mittelman@rice.edu Web: |
Education
B.S. Neurobiology, University of Texas at Dallas (2001)
Ph.D. Structural & Computational Biology and Molecular Biophysics, Baylor College of Medicine (2007)
Postdoctoral Fellowship, Department of Molecular and Human Genetics, Baylor College of Medicine (2009)
Honors
1997 - Research Grant Recipient, RISE Foundation
1998 - Academic Excellence Scholarship Recipient, University of Texas at Dallas
2003 - NEI T32 Training Grant Recipient
Research Topic
Genome Engineering
Research Description
I am interested in large and small molecule technologies for engineering changes to the genome. For a list of most recent publications, search David Mittelman at PubMed.
Selected Publications
- D. Mittelman and J.W. Fondon 3rd (2009) Nucleotide repeat mutators are tolerated in sexual populations, in preparation.
- D. Mittelman, K. Sykoudis, Y. Lin, J.H. Wilson (2009) Hsp90 modulates CAG/CTG instability in human cells, in preparation.
- D. Mittelman, C. Moye, J. Morton, K. Sykoudis, Y. Lin, D. Carroll, J.H. Wilson (2009) Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells. Proc. Natl. Acad. Sci. USA,106:9607-12.
- D.H. Morgan, D.M. Kristensen, D. Mittelman, O. Lichtarge (2006) ET Viewer: An Application for Predicting and Visualizing Functional Sites in Protein Structures. Bioinformatics, 22(16):2049-50.
- V. Gorbunova, A. Seluanov, D. Mittelman, and J.H. Wilson (2004) Demethylation of the genome strongly destabilizes CAG/CTG trinucleotide repeats in mammalian cells. Hum. Mol. Genet., 13(23):2979-2989.
- A. Seluanov, D. Mittelman, O.M. Pereira-Smith, J.H. Wilson, and V. Gorbunova (2004) DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. USA, 101(20):7624-9.
- D. Mittelman, R. Sadreyev, and N. Grishin (2003) Probabilistic scoring measures for profile-profile comparison yield more accurate short seed alignments. Bioinformatics, 19(12):1531-1539.
- R.P. Balog, Y. Ponce de Souza, H. Tang, G. DeMasellis, B. Gao, A. Avila, D. Gaban, D. Mittelman, J.D. Minna, K.J. Luebke, and H.R. Garner (2002) Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays. Analytical Biochemistry, 309(2):301-310.
- K.J. Luebke, R.P. Balog, D. Mittelman and H.R. Garner (2002) Digital Optical Chemistry: A Novel System for the Rapid Fabrication of Custom Oligonucleotide Arrays, a chapter in Microfabricated Sensors, Application of Optical Technology for DNA Analysis, Usmani and Wai Tak Law, editors, American Chemical Society Publications.
- A. Kulkarni, N. Williams, Y. Lian, J.D. Wren, D. Mittelman, A. Pertsemlidis, and H.R. Garner (2002) ARROGANT: an application to manipulate large gene collections. Bioinformatics, 18(11):1410-1417.
- J.D. Wren, D. Mittelman, and H.R. Garner (2002) SIGNAL - Sequence Information and Genomic Analysis. Computer Methods and Programs in Biomedicine, 68(2):177-181.
- A. Pertsemlidis, B. Miller, A. Pande, D. Mittelman, P. Schilling, M. Wei, M. Lerman, J. Minna, and H. Garner (2000) PANORAMA - An Integrated Web-Based Sequence Analysis Tool and Its Role in Gene Discovery. Genomics, 70(3): 300-306.
Last edited on: June 17, 2009