|
|
Timothy Palzkill
Baylor College of MedicineDepartment: Molecular Virology & MicrobiologyAddress: One Baylor Plaza, Room 244A Houston, TX 77030 Phone: 713-798-5609 Fax: 713-798-7375 Email: timothyp@bcm.tmc.edu Web: |
Education
B.S. Biology, Creighton University (1983)
Ph.D. Genetics, University of Iowa (1988)
Stanford University
Honors
1994 American Society for Microbiology Vector Laboratories Young Investigator Award
1994 American Socitey for Microbiology ICAAC Young Investigator Award
2001 National Institutes of Health MERIT Award
2002 Fellow, American Academy of Microbiology
Research Topic
Molecular Basis of Antibiotic Resistance, Functional Genomics of Bacterial Pathogens
Research Description
Protein structure and function studies on bacterial enzymes responsible for antibiotic resistance. These enzymes include beta-lactamases which catalyze the hydrolysis of penicillins and cephalosporins as well as a transpeptidase enzyme (PBP2a) from the bacterial pathogen Staphylococcus aureus which provides resistance to virtually all beta-lactam antibiotics.
Functional genomics studies on Treponema pallidum, the causative agent of syphilis. High-throughput techniques have been used to clone >95% of the open reading frames of this organism into protein expression vectors as well as vectors for phage display and two-hybrid analysis. These gene sets are being used to identify important antigens during T. pallidum infections and to map protein-protein interactions on the surface of the organism.
Selected Publications
- Zhang, Z. and Palzkill, T. (2003). Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J. Biol. Chem. 278: 45706-45712.
- Majiduddin, F.K. and Palzkill, T. (2003). An analysis of why highly similar enzymes evolve differently. Genetics 163: 457-466.
- McKevitt, M., Patel, K., Smajs, D., Marsh, M., McLoughlin, M., Norris, S.J., Weinstock, G.M. and Palzkill, T. (2003). Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res. 13: 1665-1674.
Lab Members
Current Graduate Students
Former Grad Students
Current Post Docs
Former Post Docs
Lab Photos
Last edited on: December 17, 2003